Functional analysis of a mitochondrial phosphopantetheinyl transferase (PPTase) gene pptB in Aspergillus fumigatus |
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| Authors: | Allen Gethin Bromley Mike Kaye Sarah J Keszenman-Pereyra David Zucchi Tiago D Price Jaqueline Birch Mike Oliver Jason D Turner Geoffrey |
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| Affiliation: | Department of Molecular Biology and Biotechnology, University of Sheffield, Sheffield S102TN, UK. |
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| Abstract: | The mitochondrial phosphopantetheinyl transferase gene pptB of the opportunistic pathogen Aspergillus fumigatus has been identified and characterised. Unlike pptA, which is required for lysine biosynthesis, secondary metabolism, and iron assimilation, pptB is essential for viability. PptB is located in the mitochondria. In vitro expression of pptA and pptB has shown that PptB is specific for the mitochondrial acyl carrier protein AcpA. |
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