Adenine inhibits microcyst formation inPhysarum flavicomum and affects the cellular level of S-adenosylmethionine |
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Authors: | Hiltrud U White H R Henney Jr |
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Institution: | (1) Department of Biology, University of Houston, 77004 Houston, TX, USA |
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Abstract: | Summary The effect of various purines, pyrimidines and nucleosides on the encystment of haploid cells ofPhysarum flavicomum was determined. Of the compounds tested guanine, guanosine, cytidine, cytosine, 5-methylcytosine and uracil had no effect on encystment. Adenosine, thymine, uridine and 3-methyladenine only slightly delayed encystment and protein degradation. Adenine and, to a lesser extent, hypoxanthine produced a significant inhibition of encystment and greatly increased rates of autolytic protein and RNA degradation, which eventually led to about 75% cell death in the adenine-exposed cells. The inhibition of microcyst formation by adenine was concentration dependent. The incubation of cells with adenine resulted initially in elevated intracellular levels of S-adenosylmethionine up to 3.5 times the level of untreated control cells. |
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Keywords: | Adenine Encystment Microcysts Myxomycete Physarum flavicomum S-adenosylmethionine |
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