Bcl-2 antisense oligodeoxynucleotide increases the sensitivity of leukemic cells to arsenic trioxide |
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Authors: | Zhang Y Shen W L |
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Institution: | Institute of Hematology, Medical College of Jinan University, Guangzhou 510632, China. tzyuan@jnu.edu.cn |
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Abstract: | Cell culture, tissue chemistry and flow cytometry were used to determine whether antisense bcl-2 oligodeoxynucleotides enhanced the sensitivity of leukemia cells to arsenic trioxide. A combination of arsenic trioxide with antisense bcl-2 oligodeoxynucleotides inhibited cell growth, induced apoptosis and induced bcl-2 protein expression in K562 and NB4 leukemic cells more significantly than either arsenic trioxide or the oligodeoxynucleotides on their own (P<0.01). Thus, bcl-2 antisense oligodeoxynucleotides increase the sensitivity of leukemic cells to arsenic trioxide. Combined use of the two agents could be a novel and attractive strategy in leukemia treatment. |
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Keywords: | bcl‐2 Apoptosis Arsenic trioxide Leukemia Antisense oligonucleotide |
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