Synthesis of carbamate-linked lipids for gene delivery |
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| Authors: | Liu Dongliang Hu Jianjun Qiao Weihong Li Zongshi Zhang Shubiao Cheng Lvbo |
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| Affiliation: | State Key Laboratory of Fine Chemicals, Dalian University of Technology, Dalian 116012, China. dut-liu@163.com |
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| Abstract: | Series of lipids 1a-d and 2a,b, with carbamate linkages between hydrocarbon chains and ammonium or tertiary amine head, which were pH sensitive, were synthesized for liposome-mediated gene delivery. The variable length of carbon chains and quaternary ammonium or neutral tertiary amine heads allowed to find the structure-function relationship of how these factors affect cationic lipids on gene delivery performance. |
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