Topical Treatment of Dermatophytic Lesion on Mice (<Emphasis Type="Italic">Mus musculus</Emphasis>) Model |
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Authors: | Bindu Sharma Padma Kumar Suresh Chandra Joshi |
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Institution: | (1) Laboratory of Plant Tissue Culture and Secondary Metabolites, Department of Botany, University of Rajasthan, 84/52, Mansarover, Jaipur, 302020, India;(2) Laboratory of Reproductive Toxicology, Department of Zoology, University of Rajasthan, Jaipur, 302004, India |
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Abstract: | Antidermatophytic potential of three weed plants viz. Tridax procumbens L., Capparis decidua (forsk) Edgew and Lantana camara L. were explored and experimentally induced dermatophytic lesion was topically treated in mice. Microbroth dilution method
was carried out for determination of MIC and MFC of different extracts of selected plants. In animal studies, mice were experimentally
inoculated with Trichophyton mentagrophytes and infected animals were topically treated with 5 mg/g terbinafine and two concentrations, i.e., 5 and 10 mg/g of test extract
ointment. Complete recovery from the infection was observed on 12th day of treatment for reference drug terbinafine (5 mg/g)
and 10 mg/g concentration of test extract ointment whereas 5 mg/g concentration of test extract ointment showed complete cure
on 16th day of treatment. Fungal burden was also calculated by culturing skin scrapings from infected animals of different
groups. Test extract ointment successfully treated induced dermatophytosis in mice without any disease recurrence incidences,
thereby indicating efficacy of test extract as an excellent topical antifungal agent for the cure of dermatophytosis. |
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Keywords: | Dermatophytosis Flavonoids Trichophyton mentagrophytes |
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