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Effects of leptin on in vitro maturation, fertilization and embryonic cleavage after ICSI and early developmental expression of leptin (Ob) and leptin receptor (ObR) proteins in the horse |
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| Authors: | Anna Lange Consiglio Maria Elena Dell'Aquila Nadia Fiandanese Barbara Ambruosi Yoon S Cho Giampaolo Bosi Silvana Arrighi Giovanni M Lacalandra Fausto Cremonesi |
| Institution: | 1. Reproduction Unit, Large Animal Hospital, Faculty of Veterinary Medicine, Università degli Studi di Milano, Via dell'Università 6, 26900, Lodi, Italy 2. Department of Animal Production, Faculty of Biotechnological Sciences, S Prov Casamassimakm 3, 70010, Valenzano (Bari), Italy 4. Assisted Procreation Unit, Clinica Santa Maria, Bari, Italy 3. Department of Veterinary Science and Technologies for Food Safety, Laboratory of Anatomy, via Trentacoste 2, 20134, Milano, Italy |
| Abstract: | BackgroundThe identification of the adipocyte-derived obesity gene product, leptin (Ob), and subsequently its association with reproduction in rodents and humans led to speculations that leptin may be involved in the regulation of oocyte and preimplantation embryo development. In mice and pigs, in vitro leptin addition significantly increased meiotic resumption and promoted preimplantation embryo development in a dose-dependent manner. This study was conducted to determine whether leptin supplementation during in vitro maturation (IVM) to horse oocytes could have effects on their developmental capacity after fertilization by IntraCytoplasmic Sperm Injection (ICSI). |
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