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Developmental mechanisms and adult stem cells for therapeutic lung regeneration |
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| Authors: | Joo-Hyeon Lee Emma L. Rawlins |
| Affiliation: | 1. Wellcome Trust/Medical Research Council Stem Cell Institute, University of Cambridge, Cambridge, UK;2. Department of Physiology, Development and Neurobiology, University of Cambridge, Cambridge, UK;3. Wellcome Trust/CRUK Gurdon Institute, University of Cambridge, UK;4. Department of Pathology, University of Cambridge, Cambridge, UK |
| Abstract: | Chronic degenerative lung diseases are essentially untreatable pathological conditions. By contrast, the healthy lung has numerous mechanisms that allow for rapid repair and restoration of function following minor acute injuries. We discuss the normal endogenous processes of lung development, homeostatic maintenance and repair and consider the research strategies required for the development of methods for human therapeutic lung regeneration. |
| Keywords: | Corresponding author at: Wellcome Trust/Medical Research Council Stem Cell Institute University of Cambridge Cambridge UK |
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