Mapping of theARIXHomeodomain Gene to Mouse Chromosome 7 and Human Chromosome 11q13 |
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| Authors: | Kenneth R. Johnson Leslie Smith Dabney K. Johnson Jennifer Rhodes Eugene M. Rinchik Mathew Thayer Elaine J. Lewis |
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| Affiliation: | dDepartment of Biochemistry and Molecular Biology, Oregon Health Sciences University, Portland, Oregon, 97201-3098;bDepartment of Molecular and Medical Genetics, Oregon Health Sciences University, Portland, Oregon, 97201-3098;aThe Jackson Laboratory, Bar Harbor, Maine, 04609;cBiology Division, Oak Ridge National Laboratory, PO Box 2009, Oak Ridge, Tennessee, 37831 |
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| Abstract: | The recently described homeodomain protein ARIX is expressed specifically in noradrenergic cell types of the sympathetic nervous system, brain, and adrenal medulla. ARIX interacts with regulatory elements of the genes encoding the noradrenergic biosynthetic enzymes tyrosine hydroxylase and dopamine β-hydroxylase, suggesting a role for ARIX in expression of the noradrenergic phenotype. In the study described here, the mouse and human ARIX genes are mapped. Using segregation analysis of two panels of mouse backcross DNA, mouseArixwas positioned approximately 50 cM distal to the centromere of chromosome 7, nearHbb.HumanARIXwas positioned through analysis of somatic cell hybrids and fluorescencein situhybridization of human metaphase chromosomes to chromosome 11q13.3–q13.4. These map locations extend and further define regions of conserved synteny between mouse and human genomes and identify a new candidate gene for inherited developmental disorders linked to human 11q13. |
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