家蝇抗菌肽的研究与应用

近年来,对家蝇Muscadomestica体内外抗菌活性物质的研究受到人们广泛的关注,其中研究较多的是抗菌肽。家蝇抗菌肽对细菌、真菌、肿瘤癌细胞和病毒等具有生物活性,可通过针刺、带菌针刺、超声波、放射性射线、高频电磁场和生理盐水等方法诱导增量产生,能耐极端的温度和pH值的溶液,在高浓度盐溶液中也很稳定。文章还对家蝇抗菌肽的结构特点、作用机理与分子生物学研究做了概述,同时对家蝇抗菌肽的应用前景进行了讨论。

Study and application of Musca domestica antimicrobial peptides

In recent years, the antimicrobial active substances and especially antimicrobial peptide of houseflies were investigated extensively.The antimicrobial peptides could exhibit biological activities against bacteria,fungi,cancer cells and viruses.By the treatment with acupuncture,acupuncture carrying bacteria,heat shock,ultrasonic vibration,radioactive ray,high frequency electromagnetism or physiological saline etc.,this peptide could be induced into houseflies.The antimicrobial peptide could exist stably in-20～100℃,in the solution of extreme pH value,or in the solution of concentrated saline. The structure, mode of action and molecular biology of antimicrobial peptides of houseflies were summarized,and the application prospect was discussed.