On the dimerization of the primitive tRNAs: implications in the origin of genetic code |
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Authors: | Martinez Gimenez Juan A Tabarés Seisdedos Rafael |
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Affiliation: | C/oVirgen Del Pilar, 34, 46980, Paterna, Spain |
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Abstract: | RNAs that catalyse their own aminoacylation have been recently selected in vitro. These findings support the notion that the primitive aminoacyl-tRNA synthetases may have been RNAs. In this paper, we propose a structural model for the first aminoacyl-tRNA synthetase consisting of an RNA complex formed between two primitive tRNA molecules through two intermolecular loop-strand interactions, and with implications in the origin of the genetic code. |
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