TRIC-A channels in vascular smooth muscle contribute to blood pressure maintenance |
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Authors: | Yamazaki Daiju Tabara Yasuharu Kita Satomi Hanada Hironori Komazaki Shinji Naitou Daisuke Mishima Aya Nishi Miyuki Yamamura Hisao Yamamoto Shinichiro Kakizawa Sho Miyachi Hitoshi Yamamoto Shintaro Miyata Toshiyuki Kawano Yuhei Kamide Kei Ogihara Toshio Hata Akira Umemura Satoshi Soma Masayoshi Takahashi Norio Imaizumi Yuji Miki Tetsuro Iwamoto Takahiro Takeshima Hiroshi |
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Affiliation: | Graduate School of Pharmaceutical Sciences, Kyoto University, Kyoto 606-8501, Japan. |
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Abstract: | TRIC channel subtypes, namely TRIC-A and TRIC-B, are intracellular monovalent cation channels postulated to mediate counter-ion movements facilitating physiological Ca(2+) release from internal stores. Tric-a-knockout mice developed hypertension during the daytime due to enhanced myogenic tone in resistance arteries. There are two Ca(2+) release mechanisms in vascular smooth muscle cells (VSMCs); incidental opening of ryanodine receptors (RyRs) generates local Ca(2+) sparks to induce hyperpolarization, while agonist-induced activation of inositol trisphosphate receptors (IP(3)Rs) evokes global Ca(2+) transients causing contraction. Tric-a gene ablation inhibited RyR-mediated hyperpolarization signaling to stimulate voltage-dependent Ca(2+) influx, and adversely enhanced IP(3)R-mediated Ca(2+) transients by overloading Ca(2+) stores in VSMCs. Moreover, association analysis identified single-nucleotide polymorphisms (SNPs) around the human TRIC-A gene that increase hypertension risk and restrict the efficiency of antihypertensive drugs. Therefore, TRIC-A channels contribute to maintaining blood pressure, while TRIC-A SNPs could provide biomarkers for constitutional diagnosis and personalized medical treatment of essential hypertension. |
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