Importance of the C28-C38 hydrophobic domain of okadaic acid for potent inhibition of protein serine-threonine phosphatases 1 and 2A |
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| Authors: | Frydrychowski V A Urbanek R A Dounay A B Forsyth C J |
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| Affiliation: | Department of Chemistry, University of Minnesota, Minneapolis 55455, USA. |
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| Abstract: | Okadaic acid is a potent inhibitor of select serine/threonine protein phosphatases. The importance of the C28-C38 hydrophobic domain of okadaic acid for inhibition of PP1 and PP2A was investigated. The hydrophobic domain is required but not sufficient for potent inhibition, and it also contributes to differential inhibition between PP1 and PP2A. |
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