Subunit selective alteration of hepatic glutathione transferases in spontaneously hypertensive rats |
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| Authors: | E Lee Y Miki K Kariya |
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| Institution: | Department of Pharmacology, Faculty of Pharmaceutical Sciences, Kobe-Gakuin University, Kobe, Japan. |
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| Abstract: | 1. The activities of glutathione (GSH) transferases in male, spontaneously hypertensive rats (SHR) and stroke-prone rats (SHR-SP) were different from those of normotensive male Wistar Kyoto rats (WKY). 2. These alterations of the enzyme activities were partly due to the changes in the levels of subunits 2 and 4. 3. Subunit selective alterations were observed in pathophysiological conditions, namely spontaneous hypertension. 4. The sex-related difference of GSH transferases in these animals was also discussed. |
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