Isolation and characterization of phosphonoacetic acid-resistant mutants of human cytomegalovirus. |
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Authors: | R T D''''Aquila and W C Summers |
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Abstract: | Mutants of the human cytomegalovirus (HCMV) that were 6- to 13-fold more resistant to phosphonoacetic acid than the wild-type HCMV (Towne) were isolated. Extracts from mycoplasma-free, mutant-infected cells had phosphonoacetate-resistant DNA polymerase activity in vitro. This strongly suggests that the selected mutations are in the HCMV DNA polymerase genes of these viruses. |
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