| 基因工程双特异抗体研究进展 |
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| 引用本文： | 步恒富,祝庆余,李钟铎,杨同书. 基因工程双特异抗体研究进展[J]. 生物技术通讯, 1999, 10(1): 33-37 |
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| 作者姓名： | 步恒富 祝庆余 李钟铎 杨同书 |
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| 作者单位： | 1. 军事医学科学院微生物流行病研究所,北京,100850
2. 白求恩医科大学应用基础研究所 |
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| 摘 要： | 双特异抗体特别是双特异性单链抗体、亮氨酸接链双特异性抗体、双特异性单链抗体毒素等是近几年来发展起来的很有前途的监床诊疗生物制剂 ,本文对其基因构建、边接肽设计、表达产物及活性等方面的新进展作了重点论述。
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| 关 键 词： | 双特异抗体 双特异性单链抗体 亮氨酸拉链双特异性抗体 双特异性单链抗体毒素 |
The research progress of engineering bispecific antibodies |
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| Bu Hengfu,Zhu Qingyu,Li Zhongduo,Yang Tongshu. The research progress of engineering bispecific antibodies[J]. Letters in Biotechnology, 1999, 10(1): 33-37 |
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| Authors: | Bu Hengfu Zhu Qingyu Li Zhongduo Yang Tongshu |
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| Affiliation: | Bu Hengfu, Zhu Qingyu, LiZhongduo,Yang Tongshu;(Institute of Microbiology andEpidemiology,Academy of Military Medical Sciences,Beijing 100850) |
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| Abstract: | Bispecific antibodies including bispecific shingle-chain antibody?leucine zipper dimerized bispecific ScFv antibody? bispecific single-chain antibody-toxin are very useful bilolgical products to be used in the clinical diagnosis and therapy developed in recent years, here we mainly elaborate the research progress of the gene construction?linker design?expression products and their bio-activity. |
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| Keywords: | bispecific antibodies bispecific single-chain antibody leucine ziper dimerized bispecific Scfv antibody bispecific single-chain antibody-oxin |
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