Bis-thiourea Metal Complexes with Enhanced Antiphytoviral Activity

The activity of bis-thiourea, diallyl-bis-thiourea and in part of diphenyl-bis-thiourea against potato virus X (PVX) can be augmented considerably by complexation of the mentioned compounds with Cu^±±, Ni^±±, and Co^±±. Contrary to this, complexation with Fe^±± and Cd^±± does not augment or reduce the antiphytoviral activity. Most antiphytoviral active are the diallyl-bis-thiourea complexes with Cu^±±, Ni^±± and Co^±±. The antiphytoviral activity of the Cu^±± and Cd^±± complexes with bisthiourea can be additionally augmented by combined treatment with small amounts of 2,4-dioxohexahydro-l,3,5-triazine (DHT).