Assembling the mitochondrial outer membrane |
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| Authors: | Pfanner Nikolaus Wiedemann Nils Meisinger Chris Lithgow Trevor |
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| Affiliation: | Institut für Biochemie und Molekularbiologie, Universit?t Freiburg, Hermann-Herder-Str. 7, D-79104 Freiburg, Germany. Nikolaus.Pfanner@biochemie.uni-freiburg.de |
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| Abstract: | The general preprotein translocase of the outer mitochondrial membrane (TOM complex) transports virtually all mitochondrial precursor proteins, but cannot assemble outer-membrane precursors into functional complexes. A recently discovered sorting and assembly machinery (SAM complex) is essential for integration and assembly of outer-membrane proteins, revealing unexpected connections to mitochondrial evolution and morphology. |
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