Genetic and serologic relatedness between Mycoplasma fermentans strains and a mycoplasma recently identified in tissues of AIDS and non-AIDS patients |
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| Institution: | 1. Laboratoire de Biologie cellulaire et moléculaire, Institut National de Recherche Agronomique and Université de Bordeaux II, 33140 Pont-de-la-Maye, France;2. Laboratoire de Bactériologie, Université de Bordeaux II, 33076 Bordeaux Cedex, France;3. Armed Forces Institute of Pathology, Washington, D.C. 20306, USA;4. Warren Grant Magnuson Clinical Center, National Institutes of Health, Bethesda, MD 20205, USA;5. Laboratory of Molecular Microbiology, National Institute of Allergy & Infectious Diseases, Bldg. 550, Frederick Cancer Research Facility, Frederick, MD 21701, USA;1. Pharmaceutical Outcomes and Policy, College of Pharmacy, University of Florida, Gainesville, FL, USA;2. Department of Public Health Sciences, School of Medicine, University of Virginia, Charlottesville, VA, USA;1. School of Pharmacy, University of Eastern Finland, P.O. Box 1627, 70211, Kuopio, Finland;2. Institute of Biomedicine, University of Turku, FI-20014 University of Turku, Finland;3. The Social Insurance Institution of Finland, P.O. Box 450, 00056, Kela, Finland;1. Laboratory of Teaching and Research in Social Pharmacy (LEPFS), Department of Pharmacy, Federal University of Sergipe, São Cristóvão, SE, Brazil;2. Nursing Department, Federal University of Sergipe, Campus Prof. Antônio Garcia Filho, Lagarto, SE, Brazil;1. Gold Coast Health, Gold Coast, Queensland, 4215, Australia;2. School of Pharmacy and Pharmacology, Griffith University, Gold Coast, Queensland 4222, Australia;3. School of Pharmacy and Biomedical Sciences, Faculty of Health Sciences, Curtin University, Bentley, Western Australia, 6102, Australia;1. Biophysics Unit, Department of Biochemistry and Molecular Biology, School of Medicine, Universitat Autònoma de Barcelona, 08193 Cerdanyola del Vallès, Spain;2. Institute of Neuroscience, Universitat Autònoma de Barcelona, 08193 Cerdanyola del Vallès, Spain;3. Interactions Hôtes-Agents Pathogènes (IHAP), Université de Toulouse, INRAE, ENVT, 31300 Toulouse, France;4. Laboratori de Recerca en Microbiologia i Malalties Infeccioses, Institut d’Investigació i Innovació Parc Taulí (I3PT), Hospital Universitari Parc Taulí, Universitat Autònoma de Barcelona, 08208 Sabadell, Spain;5. Institut de Biotecnologia i Biomedicina and Departament de Bioquímica i Biologia Molecular, Universitat Autònoma de Barcelona, 08193 Cerdanyola del Vallès, Spain;6. Department of Biochemistry and Biophysics, Stockholm University, Svante Arrhenius väg 16C, 10691 Stockholm, Sweden |
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| Abstract: | A mycoplasma previously identified in the tissues of both AIDS and non-AIDS patients dying of an acute fatal disease was earlier shown to share some biologic and genetic properties with a strain of Mycoplasma fermentans, an organism occurring infrequently in the human lower urogenital tract. More extensive genetic and serologic comparisons using DNA/DNA hybridization, DNA base composition (guanine + cytosine), restriction endonuclease DNA analysis, cellular protein patterns and metabolism inhibition serologic procedures confirm that the organism previously designated as “Mycoplasma incognitus” (Mi) is indeed very closely related to strains of M. fermentans. While the genetic and serologic features observed among the newly isolated mycoplasma and two M. fermentans strains suggest a species relationship, it now seems useful to re-examine the biological activities of other freshly isolated M. fermentans strains from man. |
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