Antibody response to preS1 in hepatitis-B-virus-induced liver disease and after immunization |
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| Institution: | 1. Former Graduate Student, School of Natural Resources and the Environment, University of Arizona, Tucson, AZ 85721, USA;2. Former Graduate Student, Institute of Meteorology and Hydrology, Ulaanbaatar, Mongolia 210646, Mongolia;3. Professor, Department of Forest and Rangeland Stewardship, Colorado State University, Fort Collins, CO 80523, USA;1. Professor of Terrestrial Ecology, Centre for Ecological and Evolutionary Synthesis (CEES), Department of Biosciences, University of Oslo, Oslo, Norway;7. Division Director of Grazing Research and Mapping, Norwegian Forest and Landscape Institute, Ås, Norway;3. Professor, Department of Ecology and Natural Resource Management, Norwegian University of Life Science, Ås, Norway;5. Doctoral Student, Department of Animal and Aquacultural Sciences, Norwegian University of Life Sciences, Ås, Norway;6. Professor of Animal Husbandry, Department of Animal and Aquacultural Sciences, Norwegian University of Life Sciences, Ås, Norway;1. Professor, Institute of Animal Production in the Tropics and Subtropics, University of Hohenheim, 70593 Stuttgart, Germany;2. Research Associate, Institute of Animal Nutrition and Physiology, Christian-Albrechts-Universität zu Kiel, 24098 Kiel, Germany;5. Professor, Institute of Animal Nutrition and Physiology, Christian-Albrechts-Universität zu Kiel, 24098 Kiel, Germany;3. Adjunct Professor, Institute of Crop Science and Plant Breeding–Grass and Forage Science/Organic Agriculture, Christian-Albrechts-Universität zuf Kiel, 24098 Kiel, Germany;4. Professor, Institute of Crop Science and Plant Breeding–Grass and Forage Science/Organic Agriculture, Christian-Albrechts-Universität zuf Kiel, 24098 Kiel, Germany;1. Professor, Texas A&M AgriLife Research, Vernon, TX, USA and Department of Ecosystem Science and Management, Texas A&M University, College Station, TX 76384, USA;2. Professor and Associate Department Head, Department of Ecosystem Science and Management, Texas A&M University, College Station, TX 77843-2138, USA;3. Professor, Department of Crop and Soil Sciences, Washington State University, Pullman, WA 99164-6420, USA;1. Director of Conservation Ecology, The Nature Conservancy, Reno, NV 89501, USA;2. Ecologist, Eastern Nevada Landscape Coalition, Ely, NV 89315, USA;1. PhD student and Dép. de biologie, Université de Sherbrooke, QC, J1K2R1, Canada;2. Professor, Dép. de biologie, Université de Sherbrooke, QC, J1K2R1, Canada;3. PhD student and Dép. de biologie, Université Laval, Québec, QC, G1V0A6, Canada |
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| Abstract: | Antibodies to the preS1-encoded sequence of hepatitis B virus (HBV) envelope were detected by ELISA using a synthetic peptide analogue of preS1 proteins, in different groups of HBV-infected subjects and also in hepatitis B vaccine recipients. Such antibodies were specifically found in only 1 % of HBsAg chronic carriers including patients with cirrhosis and primary liver cancer. Anti-preS1 were detected in patients with acute hepatitis; in 13 % of the HBsAg+ sera obtained before recovery and in 37 % of the sera obtained after recovery.Anti-preS1 antibodies were detected in recipients of a plasma-derived vaccine, but not in those receiving a recombinant vaccine. The results indicate that anti-preS1 is an earlier serum marker of HBV clearance than anti-preS2 and anti-S antibodies. |
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