An analysis of indeterminate Western blot patterns of black African subjects |
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| Institution: | 1. Institute of Applied Physics RAS, Nizhny Novgorod, Russia;2. Lobachevsky State University of Nizhny Novgorod, Nizhny Novgorod, Russia;3. Institute of Molecular Medicine, Sechenov First Moscow State Medical University, Moscow, Russia;1. Demirci Bio-Acoustic-MEMS in Medicine (BAMM) Laboratory, Radiology Department, Canary Center at Stanford for Cancer Early Detection, Stanford University School of Medicine, Palo Alto, CA, USA;2. State Key Laboratory for Diagnosis and Treatment of Infectious Diseases, First Affiliated Hospital, College of Medicine, Zhejiang University, Hangzhou, China;3. Collaborative Innovation Center for Diagnosis and Treatment of Infectious Diseases, Hangzhou, China;4. Institute for Translational Medicine, Zhejiang University, Hangzhou, China;5. Medicine Faculty, Zirve University, Gaziantep, Turkey;6. Division of Experimental Medicine, University of California San Francisco, San Francisco, CA, USA;1. Department of Pathology, Geisel School of Medicine at Dartmouth, Hanover, NH, United States;2. Dartmouth Hitchcock Medical Center and Norris Cotton Cancer Center, Lebanon, NH, United States;3. Department of Electrical Engineering, California Institute of Technology, Pasadena, CA, United States |
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| Abstract: | The significance of indeterminate Western blotting results was assessed by determining their distribution in attenders of sexually transmitted diseases (STD) and family planning (FP) clinics. As expected, it was found that the former had a highly significantly greater prevalence of HIV infection. Indeterminate results were not found more frequently in STD attenders refuting any association with sexual promiscuity. They were, however, found significantly more frequently amongst black compared to white subjects, but no difference was found between males and females. Indeterminate results appear to be a feature of black African sera and what the significance is, still remains to be elucidated. |
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