Towards a polymeric binding mimic for cytochrome CYP2D6 |
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Authors: | Rathbone Daniel L Ali Aisha Antonaki Polyxeni Cheek Sarah |
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Institution: | School of Life and Health Sciences, Aston University, Birmingham B4 7ET, UK. D.L.Rathbone@aston.ac.uk |
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Abstract: | A series of fluorescent molecularly imprinted polymers has been prepared with a view to generating material capable of mimicking the binding characteristics of the metabolically important cytochrome isoform CYP2D6. Such polymers would have the possibility to form the sensing element in a high-throughput assay for the prediction of CYP2D6 affinity. The imprinted polymers possessed binding-dependent fluorescence. They re-bound their templates and various cross-reactivities were encountered for test compound/drug recognition. One polymer in particular exhibited a rational discrimination amongst the related synthetic templates and was reasonably successful in recognising CYP2D6 substrates from a drug panel. |
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