Structure and mechanism of ATP-dependent proteases. |
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Authors: | M Schmidt A N Lupas D Finley |
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Institution: | Department of Cell Biology, Harvard Medical School, 240 Longwood Avenue, Boston, Massachusetts, 02115, USA. |
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Abstract: | A general paradigm for energy-dependent proteases is emerging: ATP may be used to unfold the substrate and translocate it through a narrow channel within the enzyme into a central proteolytic chamber. Different members of the family present intriguing elaborations on this model. |
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