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Promoter polymorphisms in the chitinase 3-like 1 gene influence the serum concentration of YKL-40 in Danish patients with rheumatoid arthritis and in healthy subjects |
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| Authors: | Kaspar R Nielsen Rudi Steffensen Martin Boegsted John Baech Soeren Lundbye-Christensen Merete L Hetland Sophine B Krintel Hans E Johnsen Mette Nyegaard Julia S Johansen |
| Institution: | (1) Department of Clinical Immunology, Aalborg Hospital, Aarhus University Hospital, Reberbansgade, Pobox 561, 9000 Aalborg, Denmark;(2) Department of Haematology, Aalborg Hospital Science and Innovation Center, Aarhus University Hospital, Soenderskovvej 15, 9000 Aalborg, Denmark;(3) Department of Cardiology, Center for Cardiovascular Research, Aalborg Hospital, Aarhus University Hospital, Soenderskovvej 15, 9000 Aalborg, Denmark;(4) Department of Rheumatology, Copenhagen University Hospital, Hvidovre and Glostrup, Ndr, Ringvej 57, 2600 Glostrup, Denmark;(5) Department of Medicine, Copenhagen University Hospital, Herlev - Ringvej 75, 2730 Herlev, Denmark;(6) Department of Oncology, Copenhagen University Hospital, Herlev - Ringvej 75, 2730 Herlev, Denmark |
| Abstract: | IntroductionThe present study investigates the association between single nucleotide polymorphisms (SNPs) in the chitinase 3-like 1 (CHI3L1) gene and serum concentrations of YKL-40 in Danish patients with rheumatoid arthritis (RA) and healthy controls as well as the association with RA in the Danish population. The CHI3L1 gene is located on chromosome 1q32.1 and encodes the YKL-40 glycoprotein. YKL-40 concentrations are elevated in the serum of patients with RA compared to healthy subjects, and YKL-40 has been suggested to be an auto-antigen and may play a role in development of RA and in inflammation. |
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