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Syntheses, characterization and antimicrobial activity of the first complexes of Zn(II), Cd(II) and Co(II) with N-benzyloxycarbonylglycine: X-ray crystal structure of the polymeric Cd(II) complex |
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| Authors: | Djenana U. Miodragovi? Dragana M. Miti? Goran A. Bogdanovi? Maja D. Vitorovi? Branislav J. Nastasijevi? Katarina K. An?elkovi? |
| Affiliation: | a Faculty of Chemistry, University of Belgrade, P.O. Box 158, Studentski trg 12-16, 11000 Belgrade, Serbia b Faculty of Stomatology, University of Belgrade, Dr. Suboti?a 8, 11000 Belgrade, Serbia c Vin?a institute of Nuclear Sciences, Laboratory of Theoretical Physics and Condensed Matter Physics, 11000 Belgrade, P.O. Box 522, Serbia d Department of Chemistry, Institute of Chemistry, Technology and Metallurgy, University of Belgrade, Studentski trg 14, 11000 Belgrade, Serbia |
| Abstract: | For the first time, complexes of Zn(II), Cd(II) and Co(II) (1-3) with N-benzyloxycarbonylglycine have been synthesized and characterized. The complexes adopt tetrahedral, pentagonal-bipyramidal and octahedral geometry, respectively. The structure of the polymeric cadmium complex was resolved by single crystal X-ray analysis. The cadmium ion has a distorted pentagonal-bipyramidal coordination formed by two water molecules and two N-benzyloxycarbonylglycinato ligands (N-Boc) coordinated in different fashions, one as bidentate and the second connecting three cadmium atoms. In a rather complicated 2D supramolecular structure, the phenyl rings interact mutually exclusively by the CH?π interactions.Investigation of the antimicrobial activity of the obtained complexes and N-benzyloxycarbonylglycine revealed that the ligand does not inhibit the growth of Candida albicans, whereas the newly synthesized complexes suppress the growth of this human fungal pathogen. |
| Keywords: | Zinc(II), Cadmium(II) and Cobalt(II) complexes N-Boc-glycine X-ray DFT Microbiological assay |
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