Therapeutic application of various immunostimulators on the L2C guinea-pig leukemia |
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| Authors: | D L Klein W Brown P Cote W Garner J W Pearson |
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| Institution: | (1) Viral Immunotherapy Section, Laboratory of RNA Tumor Viruses, National Cancer Institute, National Institutes of Health, 20014 Bethesda, Maryland, USA;(2) Flow Laboratory, Inc., 1710 Chapman Avenue, 20852 Rockville, Maryland, USA |
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| Abstract: | Summary Immunostimulators such as Corynebacterium parvum (C. parvum), Bacillus Calmette-Guerin (BCG), pyran copolymer, and glucan were examined in the guinea pig L
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C lymphoblastic leukemia model to determine their capacity for therapeutic modulation of the immune response of the host toward controlling leukemic cell proliferation. The dose, route, and frequency of administration of the stimulators were also evaluated as a function of time in order to obtain an optimal antileukemic effect. Results indicated that only C. parvum and BCG were capable of significantly increasing host survival when given 1 day after an inoculation of 1.5×10
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viable leukemic cells. Administration of BCG or C. parvum, alone or in combination with irradiated blast cells on either days 4 or 7, was totally ineffective in prolonging survival. In the majority of cases, enhanced leukemic growth was observed on these days. The combination of BCG and/or C. parvum with irradiated syngeneic blast cells given 24 h after leukemia inoculation promoted a synergistic response with a significant increase in median survival time and a number of long-term survivors.This work was supported by contract N01-CP-53566 within the Virus Cancer Program of the National Cancer Institute |
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