Synthesis and antiviral activity of azoles obtained from carbohydrates |
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Authors: | Barradas José Sebastián Errea María Inés D'Accorso Norma B Sepúlveda Claudia S Talarico Laura B Damonte Elsa B |
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Affiliation: | CIHIDECAR-CONICET, Departamento de Química Orgánica, Facultad de Ciencias Exactas y Naturales, Universidad de Buenos Aires, Pabellón 2, Ciudad Universitaria, 1428 Buenos Aires, Argentina. |
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Abstract: | Herein we describe the synthesis of 1,2,4-triazolyl-3-thione;1,3,4-oxadiazole, and imidazo[2,1-b]thiazole derivatives from carbohydrates. The antiviral activity of these compounds was tested against Dengue and Junin virus (the etiological agent of Argentine hemorrhagic fever). The 3-(p-bromobenzoyl)-5-(1,2-O-isopropylidene-3-O-methyl-alpha-d-xylofuranos-5-ulos-5-yl)imidazo[2,1-b]thiazole was able to inhibit the replication of both viruses in Vero cells at concentration significantly lower than the CC(50). |
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Keywords: | 1,2,4-Triazolyl-3-thione 1,3,4-Oxadiazole Imidazo[2,1-b]thiazole Carbohydrates Antiviral activity |
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