The host antigen phenomenon in experimental murine schistosomiasis: The transfer of 3-week old Schistosoma mansoni between two inbred strains of mice |
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Authors: | Markley H. Boyer Dana G. Ketchum Peter D. Palmer |
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Affiliation: | Departments of Tropical Public Health and Microbiology, Harvard School of Public Health, 665 Huntington Avenue, Boston, MA 02115, U.S.A. |
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Abstract: | A surgical technique for the transfer of 3-week old Schistosoma mansoni to the mesenteric veins of mice is described. Parasites grown in a donor C3H/StCrl strain survive on transfer to recipient C57BL/10J mice despite prior immunization with C3H/StCrl cells or skin grafts. The findings indicate that the ‘species-specific’ mouse host antigens associated with adult worms in xenogeneic transfers do not have an allogeneic basis in these two strains. |
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Keywords: | Schistosomiasis helminths trematodes immunity host antigen parasites |
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