HCMV infection attenuates hydrogen peroxide induced endothelial apoptosis-- involvement of ERK pathway |
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Authors: | Wang Jing Shen Ying H Utama Budi Wang Jian LeMaire Scott A Coselli Joseph S Vercellotti Greg M Wang Xing Li |
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Institution: | Division of Cardiothoracic Surgery, Michael E. DeBakey Department of Surgery, Adult Cardiac Services, Texas Heart Institute, St. Luke's Episcopal Hospital, Baylor College of Medicine, MS NAB 2010, One Baylor Plaza, Houston, TX 77030, USA. |
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Abstract: | Human cytomegalovirus (HCMV) exerts anti-apoptotic effect during early stage of infection, which provides HCMV time for propagation. We investigated pathways mediating the resistance to H(2)O(2)-induced cell death - a self-defense mechanism to remove infected cells. We found that human aortic endothelial cells (HAECs) infected with VHL/E strain of HCMV during first 3 days were resistant to H(2)O(2) (0-2 mM) induced apoptosis. This anti-apoptotic effect may be mediated by the upregulation of Bcl-2, an anti-apoptotic protein through the activation pro-survival pathway extracellular signal regulated kinase (ERK). Through this mechanism, HCMV is able to propagate and causes endothelial dysfunction, hence vascular disease. |
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Keywords: | Endothelium Apoptosis Hydrogen peroxide Cytomegalovirus |
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