AlphaPIX and betaPIX and their role in focal adhesion formation |
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| Authors: | Rosenberger Georg Kutsche Kerstin |
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| Institution: | 1. University of California, San Francisco, Comprehensive Cancer Center, San Francisco, California, USA;2. Division of Experimental Animal Research, Chiba Cancer Center Research Institute, Chiba, Japan;3. Department of Veterinary Medicine, Resource Centre for Comparative Genomics, Cambridge University, Cambridge, UK;4. Division of Molecular Medicine, Cancer Research UK Cell Structure Research Group, University of Dundee College of Life Sciences, Dundee, UK;5. Clinical Genetics Centre, Aberdeen Royal Infirmary, Aberdeen, UK;6. Institute of Medical Biology, Singapore, Singapore;7. Department of Anatomy and Institute of Human Genetics, Helen Diller Family Comprehensive Cancer Center, University of California, San Francisco, San Francisco, California, USA;8. Department of Human Genetics, Ninewells Hospital and Medical School, Dundee, UK;1. Iran University of Medical Sciences, Medical School, Biochemistry Department, Iran;2. Iran University of Medical Sciences, School of Medicine-International Branch, Iran;3. Iran University of Medical Sciences, Cellular and Molecular Research Center, Iran |
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| Abstract: | Alpha and betaPIX belong to the group of guanine nucleotide exchange factors (GEFs) that mediate activation of members of the Rho GTPase family, in particular Rac1 and Cdc42, by stimulating the exchange of GDP for GTP. Rho family proteins are well known as regulators of the actin cytoskeleton and have been implicated in the formation of various types of focal adhesion structures. However, the function of GEF proteins during focal adhesion formation is only beginning to emerge. Here, we highlight the recent findings on alpha and betaPIX and their involvement in integrin-dependent signaling and suggest models for the role of PIX proteins during focal adhesion turnover. |
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| Keywords: | Parvin Calpain GIT p95-APP p95PKL CAT PAK Paxillin Integrin cluster Focal complex |
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