| Angiogenesis, Kaposi＇s Sarcoma and Kaposi＇s Sarcomaassociated Herpesvirus |
| |
| 作者单位： | [1]Tumor Virology Group, State Key Laboratory of Virology, Wuhan Institute of Virology, Chinese Academy of Sciences, Wuhan 430071, China [2]Graduate School of the Chinese Academy of Sciences, Beijing 100039, China [3]Tumor Virology Program, Greehey Children＇s Cancer Research Institute and Department of Pediatrics, The University of Texas Health Science Center at San Antonio, San Antonio, Texas, USA |
| |
| 基金项目： | The Knowledge Innovation Program of the Chinese Academy of Sciences Chinese Academy of Sciences，Open Research Fund Program of the State Key Laboratory of Virology of China，A Type B Outstanding Abroad Young Scientist Award |
| |
| 摘 要： |
|
| 关 键 词： | 血管 卡波西氏肉瘤 疱疹病毒 临床分析 |
| 收稿时间： | 14 August 2008 |
Angiogenesis,Kaposi's Sarcoma and Kaposi's Sarcoma-associated Herpesvirus |
| |
| Authors: | Tao Kang Feng-chun Ye Shou-jiang gao Lin-ding Wang |
| |
| Institution: | 1.Tumor Virology Group, State Key Laboratory of Virology, Wuhan Institute of Virology, Chinese Academy of Sciences, Wuhan 430071, China2.Graduate School of the Chinese Academy of Sciences, Beijing 100039, China3.Tumor Virology Program, Greehey Children's Cancer Research Institute and Department of Pediatrics, The University of Texas Health Science Center at San Antonio, San Antonio, Texas, USA |
| |
| Abstract: | Tumor angiogenesis is the uncontrolled growth of blood vessels in tumors,serving to supply nutrients and oxygen,and remove metabolic wastes.Kaposi's sarcoma (KS),a multifocal angioproliferative disorder characterized by spindle cell proliferation,neo-angiogenesis,inflammation,and edema,is associated with infection by Kaposi's sarcoma-associated herpesvirus (KSHV).Recent studies indicate that KSHV infection directly promotes angiogenesis and inflammation through an autocrine and paracrine mechanism by inducing pro-angiogenic and pro-inflammatory cytokines.Many of these cytokines are also expressed in KS lesions,implicating a direct role of KSI-IV in the pathogenesis of this malignancy.Several KSHV genes are involved in KSHV-induced angiogenesis.These studies have provided insights into the pathogenesis of KS,and identified potential therapeutic targets for this malignancy. |
| |
| Keywords: | Angiogenesis Kaposi's sarcoma (KS) Kaposi's sarcoma-associated herpesvirus (KSHV) |
| 本文献已被 维普 万方数据 SpringerLink 等数据库收录！ |
| 点击此处可从《中国病毒学》浏览原始摘要信息 |
| 点击此处可从《中国病毒学》下载免费的PDF全文 |
|
