Deletion analysis of the SMN and NAIP genes in Kuwaiti patients with spinal muscular atrophy |
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Authors: | E Samilchuk Brendan D’Souza Leila Bastaki Sadika Al-Awadi |
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Institution: | (1) Kuwait Medical Genetics Center, Ministry of Health, P.O. Box 31121, Sulaibikhat, 80901, Kuwait Tel./Fax: +965-266-3598; e-mail voevodin@hscc.kuniv.edu.kw, KW |
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Abstract: | Two genes are known to be involved in spinal muscular atrophy (SMA), namely, SMN (survival motor neuron) and NAIP (neuronal
apoptosis inhibitory protein). Deletion analysis of these genes has been reported for many ethnic groups. We have extended
this analysis to include 15 Arabic patients (11 unrelated cases of type I, which represent practically all of the patients
diagnosed within the last 2 years in Kuwait, and 4 type-II cases from a single kinship). Also, 41 healthy relatives (parents
and sibs) and 44 control individuals of Arabic origin were analyzed. The homozygous deletions of exons 7 and 8 of the SMN
gene were found in all SMA patients studied. Exon 5 of NAIP was homozygously absent in all type-I patients, but was retained
in type-II cases. Among members of SMA families, one mother was found to be homozygously deleted for NAIP. All of the control
individuals had both normal SMN and NAIP. Our results are in agreement with the general consensus that the incidence of NAIP
deletion is higher in the more severe SMA cases. Furthermore, they suggest that SMA type-I chromosomes, with the dual deletion
of the SMN and NAIP genes, are more common in Arabs than in patients of other ethnic origin.
Received: 23 April 1996 / Revised: 17 June 1996 |
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