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Diverse spatial,temporal, and sexual expression of recently duplicated androgen-binding protein genes in <Emphasis Type="Italic">Mus musculus</Emphasis> |
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| Authors: | Christina?M?Laukaitis Stephen?R?Dlouhy Richard?D?Emes Chris?P?Ponting |
| Institution: | (1) Department of Biological Sciences, Butler University, 4600 Sunset Ave, 46208 Indianapolis, Indiana, USA;(2) Internal Medicine Residency Program, St. Vincent Hospital, 2001 W. 86th St, 46260 Indianapolis, Indiana, USA;(3) Department of Medical and Molecular Genetics, Indiana University School of Medicine, 875 W. Walnut St., Medical Research and Library Building, 46202 Indianapolis, Indiana, USA;(4) MRC Functional Genetics Unit, Department of Human Anatomy and Genetics, University of Oxford, South Parks Road, OX1 3QX Oxford, UK;(5) Department of Biology, University College London, Darwin Building, Gower St., WC1E 6BT London, UK |
| Abstract: | BackgroundThe genes for salivary androgen-binding protein (ABP) subunits have been evolving rapidly in ancestors of the house mouse Mus musculus, as evidenced both by recent and extensive gene duplication and by high ratios of nonsynonymous to synonymous nucleotide substitution rates. This makes ABP an appropriate model system with which to investigate how recent adaptive evolution of paralogous genes results in functional innovation (neofunctionalization). |
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