Ethanol exerts dual effects on calcium homeostasis in CCK-8-stimulated mouse pancreatic acinar cells |
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| Authors: | Marcela Fernández-Sánchez Angel del Castillo-Vaquero Ginés M Salido Antonio González |
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| Affiliation: | (1) Department of Physiology (Cell Physiology Research Group), University of Extremadura, C?ceres, Spain |
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| Abstract: | Background A significant percentage of patients with pancreatitis often presents a history of excessive alcohol consumption. Nevertheless, the patho-physiological effect of ethanol on pancreatitis remains poorly understood. In the present study, we have investigated the early effects of acute ethanol exposure on CCK-8-evoked Ca2+ signals in mouse pancreatic acinar cells. Changes in [Ca2+]i and ROS production were analyzed employing fluorescence techniques after loading cells with fura-2 or CM-H2DCFDA, respectively. |
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