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The response to oestrogen deprivation of the cartilage collagen degradation marker, CTX-II, is unique compared with other markers of collagen turnover |
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| Authors: | Anne-Christine Bay-Jensen Nadine CB Tabassi Lene V Sondergaard Thomas L Andersen Frederik Dagnaes-Hansen Patrick Garnero Moustapha Kassem and Jean-Marie Delaissé |
| Institution: | (1) Department of Clinical Cell Biology, IRS/CSFU, University of Southern Denmark, Vejle Hospital, Kabbeltoft 25, 7100 Vejle, Denmark;(2) Department of Biomarkers, Synarc, 16, rue Montbrillant, Buroparc T4, 69416 cedex 03, LYON, France;(3) Institute of Human Genetics, University of Aarhus, Wilhelm Meyers All?, build. 1240, 8000 ?rhus C, Denmark;(4) Department of Microbiology and immunology, University of Aarhus, Wilhelm Meyers All?, build. 1240, 8000 ?rhus C, Denmark;(5) Department of Clinical Endocrinology and Molecular Biology, University of Southern, Winsloev Parken 25, 5000 Odense C, Denmark |
| Abstract: | IntroductionThe urinary level of the type II collagen degradation marker CTX-II is increased in postmenopausal women and in ovariectomised rats, suggesting that oestrogen deprivation induces cartilage breakdown. Here we investigate whether this response to oestrogen is also true for other type II collagen turnover markers known to be affected in osteoarthritis, and whether it relates to its presence in specific areas of cartilage tissue. |
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