Caveolae: stable membrane domains with a potential for internalization |
| |
Authors: | Hommelgaard Anette M Roepstorff Kirstine Vilhardt Frederik Torgersen Maria L Sandvig Kirsten van Deurs Bo |
| |
Institution: | Structural Cell Biology Unit, Department of Medical Anatomy, The Panum Institute, University of Copenhagen, DK-2200 Copenhagen N, Denmark. |
| |
Abstract: | The role of caveolae in endocytosis is hotly debated. Here, we argue that most caveolae are stable microdomains at the cell surface. Only a small fraction of caveolae is constitutively internalized, leading to a quantitatively minor uptake of ligands and receptors. In addition, we suggest that a more pronounced downregulation of caveolae from the plasma membrane can occur, presumably stimulated by receptor cross-linking and clustering in caveolae. Finally, we propose that future studies dealing with internalization of caveolae should actually document such internalization and include kinetic data. |
| |
Keywords: | Caveolae Cholera toxin endocytosis receptor cross-linking virus |
本文献已被 PubMed 等数据库收录! |
|