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QSAR of the inhibition of angiogenesis by TNP-470 and ovalicin analogues: another example of an allosteric interaction |
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| Authors: | Suresh Babu Mekapati Corwin Hansch |
| Institution: | Department of Chemistry, Pomona College, Claremont, CA 91711, USA |
| Abstract: | QSAR have been formulated for variations of TNP-470 and Ovalicin on various cell lines. In the examples of mouse lymphocyte cells and bovine endothelial cells the results suggest an allosteric interaction. These results are compared with the binding of nitrobenzene to hemoglobin in rats in vivo. Such a reaction does not occur with methionine aminopeptidase. |
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