A Novel Plasmid Gene Involved in Bacteriophage PRD1 Infection and Conjugative Host-Range |
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| Authors: | Martin Hol?iacute k,V.N. Iyer |
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| Affiliation: | Department of Biology and Institute of Biochemistry, Carleton University, Ottawa, Ontario, Canada, K1S 5B6 |
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| Abstract: | PRD1 infects bacteria carrying IncN plasmids by binding to their conjugative pili. Mutations in a plasmid locuskikAclose to the pilus region result in PRD1 resistance and reduced conjugation proficiency toKlebsiellabut not toEscherichia coli.One of the two genes ofkikAis sufficient to restore both normal phenotypes. PRD1 binds to cells carrying the mutant plasmid but fails to inject its genome. |
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