Transcription: surprising role for an elusive small nuclear RNA |
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| Authors: | Blencowe Benjamin J |
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| Affiliation: | Banting and Best Department of Medical Research, C.H. Best Institute, University of Toronto, 112 College Street, Room 410, Ontario, M5G 1L6, Toronto, Canada. b.blencowe@utoronto.ca |
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| Abstract: | Since 7SK was discovered as an abundant small nuclear RNA in the mid-70s, its role has remained tantalizingly unsolved. Two recent studies have shown that 7SK acts as a negative regulator of the RNA polymerase II elongation factor P-TEFb, and that this activity is influenced by stress response pathways. |
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