Immunogenicity and efficacy of an anthrax/plague DNA fusion vaccine in a mouse model |
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| Authors: | Albrecht Mark T Eyles Jim E Baillie Les W Keane-Myers Andrea M |
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| Affiliation: | Biological Defense Research Directorate, Naval Medical Research Center, Fort Detrick, MD, USA. |
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| Abstract: | The efficacy of multi-agent DNA vaccines consisting of a truncated gene encoding Bacillus anthracis lethal factor (LFn) fused to either Yersinia pestis V antigen (V) or Y .?pestis F1 was evaluated. A/J mice were immunized by gene gun and developed predominantly IgG1 responses that were fully protective against a lethal aerosolized B.?anthracis spore challenge but required the presence of an additional DNA vaccine expressing anthrax protective antigen to boost survival against aerosolized Y.?pestis. |
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