Genetic variations in chemoattractant receptor expressed on Th2 cells (CRTH2) is associated with asthma susceptibility in Chinese children |
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| Authors: | Jinhui Wang Yongchen Xu Hong Zhao Hong Sui Hongyan Liang Xiaofeng Jiang |
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| Institution: | (1) Department of Clinical Laboratory, The Second Affiliated Hospital of Harbin Medical University, Harbin, 150086, China;(2) Department of Clinical Laboratory, The Fourth Affiliated Hospital of Harbin Medical University, Harbin, 150001, China;(3) Department of Blood Transfusion, The Second Affiliated Hospital of Harbin Medical University, Harbin, 150086, China;(4) Department of Oncology, The Third Affiliated Hospital of Harbin Medical University, Harbin, 150080, China |
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| Abstract: | We investigated the allele and genotype frequencies of two common CRTH2 single nucleotide polymorphisms (SNPs) G1544C and
A1651G (rs 545659)] in the 3′-untranslated region and the relationship between these SNPs and serum IL-13 levels in Chinese
children patients with asthma. For G1544C and A1651G SNPs, there were significant differences in allele and genotype frequencies
between asthma patients and controls. Haplotype analysis yielded additional evidence of linkage disequilibrium for the 1544G–1651G
haplotype (P < 0.01). Moreover, serum IL-13 levels were significantly different among genotypes in G1544C, A1651G SNPs. These results
suggest that SNPs of G1544C and A1651G might be act as susceptibility genetic factors of asthma.
Jinhui Wang and Yongchen Xu should be regarded as joint First Authors. |
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| Keywords: | CRTH2 gene Single nucleotide polymorphism Interleukin-13 Asthma |
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