Cell surface dynamics of CFTR: the ins and outs |
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| Authors: | Okiyoneda Tsukasa Lukacs Gergely L |
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| Institution: | Hospital for Sick Children Research Institutes, Cell Biology, 555 University Av., Toronto, Ontario, Canada M5G 1X8. |
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| Abstract: | Ganeshan et al. (Biochem Biophys. Acta 1173 (2007) 192-200) recent study documents the effect of N-WASP inhibition and actin cytoskeleton disruption on the constitutive internalization and recycling of the cystic fibrosis transmembrane conductance regulator (CFTR) channel. The results implicate the cytoskeleton network as a potential modulator of immobilized CFTR pool size at the plasma membrane and the recycling efficiency of endocytosed channel back to the cell surface. |
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