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Effect of disulfiram on turnover of 5-hydroxytryptamine in rat brain. |
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| Authors: | R Fukumori A Minegishi T Satoh H Kitagawa S Yanaura |
| Institution: | 1. Department of Biochemical Pharmacology Faculty of Pharmaceutical Sciences, Chiba University Chiba, Japan;7. Department of Pharmacology Hoshi College of Pharmacy Tokyo, Japan |
| Abstract: | Effect of disulfiram on 5-hydroxytryptamine (5-HT) turnover was studied. Treatment with disulfiram caused increases in 5-HT and 5-hydroxyindoleacetic acid (5-HIAA) in rat brain. Under the same condition, activity of brain mitochondrial aldehyde dehydrogenase was reduced, however, supernatant aldehyde dehydrogenase and monoamine oxidase activities remained unchanged. Disulfiram had no effect on synthesis rate of 5-HT, but decreased metabolism of 5-HT. Moreover, disulfiram impaired transport of 5-HIAA from brain tissue. |
| Keywords: | Reprint requests to: Dr Tetsuo Satoh Department of Biochemical Pharmacology Faculty of Pharmaceutical Sciences Chiba University Yayoi-cho 1-33 Chiba 260 Japan |
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