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Design and analysis of drug combination experiments |
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| Authors: | Straetemans Roel O'Brien Timothy Wouters Luc Van Dun Jacky Janicot Michel Bijnens Luc Burzykowski Tomasz Aerts Marc |
| Institution: | Limburgs Universitair Centrum, Center for Statistics, Biostatistics, Universitaire Campus, B-3590 Diepenbeek, Belgium. Roel.Straetemans@luc.ac.be |
| Abstract: | In this paper we present and discuss a novel, simple and easy to implement parametric modeling approach to assess synergy. An extended three parameter log-logistic model is used to analyse the data and calculate confidence intervals of the interaction indices. In addition the model corrects for the bias due to plate-location effects. The analysis is performed with PROC NLMIXED and SAS-code is provided. The approach is illustrated using data coming from an oncology study in which the inhibition effect of a combination of two compounds is studied using 96-well plates and a fixed-ratio design. |
| Keywords: | 96‐well plates Antagonism Interaction index Drug combination Drug interaction Fixed‐ratio design Hill model Ray design Synergy Pharmacology Plate‐location effects |
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