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Collaboration between mitochondria and the nucleus is key to long life in Caenorhabditis elegans
Affiliation:1. European Molecular Biology Laboratory Hamburg, Notkestrasse 85, 22603 Hamburg, Germany;2. European Molecular Biology Laboratory Heidelberg, Meyerhofstrasse 1, 69117 Heidelberg, Germany;1. Department of Surgery, Mayo Clinic, Rochester, MN;2. Department of Biomedical Statistics and Informatics, Mayo Clinic, Rochester, MN;3. Department of Surgery, Ohio State University Medical Center, Columbus, OH;4. Department of Surgery, MetroHealth Medical Center, Cleveland, OH;5. Department of Surgery, H Lee Moffitt Cancer Center, Tampa, FL;6. Department of Surgery, Memorial Sloan Kettering Cancer Center, New York, NY;7. Department of Surgical Oncology, John Wayne Cancer Institute, Santa Monica, CA;8. Department of Surgery, Duke University School of Medicine, Durham, NC;9. Division of General Surgery, University of Wisconsin School of Medicine and Public Health, Madison, WI;10. Department of Surgery, Mayo Clinic, Phoenix, AZ;11. Department of Surgery, Fox Chase Cancer Center, Philadelphia, PA;12. Department of Surgery, Northwestern University Feinberg School of Medicine, Chicago, IL;13. Department of Surgery, University of Texas Medical Branch, Galveston, TX;1. Indian Institute of Technology Madras, Chennai 600036, India;2. University of Oxford, Denys Wilkinson Building, Keble Road, Oxford, OX1 3RH, United Kingdom;3. Pacific Northwest National Laboratory, Richland, WA 99352, USA;4. Wayne State University, Detroit, MI 48202, USA;5. Carnegie Mellon University, Pittsburgh, PA 15213, USA;6. University of Warwick, Coventry, CV4 7AL, United Kingdom;7. Luther College, Decorah, IA 52101, USA;8. University of Bristol, Bristol, BS8 1TL, United Kingdom;9. STFC Rutherford Appleton Laboratory, Chilton, Didcot, Oxfordshire, OX11 0QX, United Kingdom
Abstract:Recent findings in diverse organisms strongly support a conserved role for mitochondrial electron transport chain dysfunction in longevity modulation, but the underlying mechanisms are not well understood. One way cells cope with mitochondrial dysfunction is through a retrograde transcriptional reprogramming response. In this review, we primarily focus on the work that has been performed in Caenorhabditis elegans to elucidate these mechanisms. We describe several transcription factors that participate in mitochondria-to-nucleus signaling and discuss how they mediate the relationship between mitochondrial dysfunction and life span.
Keywords:Mitochondrial electron transport chain  Aging  Longevity  Transcription factors  Retrograde signaling  Free radicals
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