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Hypermethylation of the Keap1 gene inactivates its function,promotes Nrf2 nuclear accumulation,and is involved in arsenite-induced human keratinocyte transformation
Institution:1. Department of Pathology, School of Basic Medical Sciences, Southern Medical University, Guangzhou 510515, China;2. Department of Surgery, Nanfang Hospital, Southern Medical University, Guangzhou 510515, China;3. School of Nursing, University of South China, Hengyang 421001, China;1. Department of Toxicology, Guangzhou Key Laboratory of Environmental Pollution and Health Risk Assessment, School of Public Health, Sun Yat-sen University, Guangzhou, China;2. Key Laboratory of Environmental Pollution Monitoring and Disease Control, Ministry of Education, Department of Toxicology, School of Public Health, Guizhou Medical University, Guiyang, Guizhou, China
Abstract:
Keywords:Arsenite  Carcinogenesis  Keap1  Methylation  Nrf2  Free radicals
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