Mechanisms and functions of Nrf2 signaling in Drosophila |
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| Affiliation: | 1. King’s College London, UK;2. University of California-Merced, USA;3. Tohoku University, Japan;4. University of Pittsburgh, USA;5. University of Dundee, UK;1. Department of Nutrition, Chung Shan Medical University, No. 110, Sec. 1, Chien-Kuo N. Rd., Taichung 40203, Taiwan, ROC;2. Vascular and Genomic Center, Changhua Christian Hospital, Changhua 50094, Taiwan, ROC;3. Graduate Institute of Integrated Medicine, College of Chinese Medicine, China Medical University, No.91, Hsueh-Shih Road, Taichung 40402, Taiwan, ROC;4. Department of Medical Research, China Medical University Hospital, Taichung 40447, Taiwan, ROC;5. Department of Nutrition, Chung Shan Medical University Hospital, Taichung 40203, Taiwan, ROC;6. Department of Life Science and Life Science Research Center, Tunghai University, Taichung 40704, Taiwan, ROC;7. Department of Nutrition, China Medical University, Taichung 40402, Taiwan, ROC;8. Department of Biomedical Sciences, Chung Shan Medical University, Taichung 40203, Taiwan, ROC;9. Department of Food Nutrition and Health Biotechnology, Asia University, Taichung, Taiwan, ROC;10. Department of Neurology and Vascular and Genomic Center, Changhua Christian Hospital, Changhua 50094 Taiwan, ROC;1. School of Basic Medicine and Biological Sciences, Soochow University, Suzhou, Jiangsu, 215123, PR China;2. Sericulture Institute of Soochow University, Suzhou, Jiangsu, 215123, PR China;3. Jiangsu Key Laboratory of Environmental Science and Engineering, Suzhou University of Science and Technology, Suzhou, Jiangsu, 215009, PR China;1. Ethel Percy Andrus Gerontology Center, Leonard Davis School of Gerontology;2. Division of Molecular & Computational Biology, Department of Biological Sciences, Dornsife College of Letters, Arts, and Sciences, The University of Southern California, Los Angeles, CA 90089-0191, USA;3. School of Natural Science, University of California at Merced, Merced, CA 95344, USA;1. Research Division, Joslin Diabetes Center, One Joslin Place, Boston, MA 02215, USA;2. Department of Genetics and Harvard Stem Cell Institute, Harvard Medical School, Boston, MA 02215, USA |
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| Abstract: | The Nrf2 transcription factor belongs to the Cap’n’collar family, named after the founding member of this group, the product of the Drosophila Cap’n’collar gene. The encoded protein, Cap’n’collar, abbreviated Cnc, offers a convenient and accessible model to study the structure, function, and biology of Nrf2 transcription factors at the organismic, tissular, cellular, and molecular levels, using the powerful genetic, genomic, and biochemical tools available in Drosophila. In this review we provide an account of the original identification of Cnc as a regulator of embryonic development. We then describe the discovery of Nrf2-like functions of Cnc and its role in acute stress signaling and aging. The establishment of Drosophila as a model organism in which the mechanisms and functions of Nrf2 signaling can be studied has led to several discoveries: the regulation of stem cell activity by an Nrf2-mediated redox mechanism, the interaction of Nrf2 with p62 and Myc in the control of tissue growth and the unfolded protein response, and more. Several of these more recent lines of investigation are highlighted. Model organisms such as the fly and the worm remain powerful experimental platforms that can help to unravel the many remaining puzzles regarding the role of Nrf2 and its relatives in controlling the physiology and maintaining the health of multicellular organisms. |
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| Keywords: | Drosophila Nrf2 Maf-S Keap1 Aging Oxidative stress Free radicals |
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