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The antioxidant function of sestrins is mediated by promotion of autophagic degradation of Keap1 and Nrf2 activation and by inhibition of mTORC1
Institution:1. Liggins Institute, The University of Auckland, Private Bag 92 019, Victoria Street West, Auckland 1142, New Zealand;2. Food & Bio-based Products Group, AgResearch, Palmerston North 4474, New Zealand;3. Riddet Institute, Palmerston North 4442, New Zealand;1. Department of Cardiology, Renmin Hospital of Wuhan University, Cardiovascular Research Institute, Wuhan University; Hubei Key Laboratory of Cardiology, Wuhan 430060, China;2. Department of Cardiology, the People''s Hospital of Guangxi Zhuang Autonomous Region, Nanning, China;1. Department of Physiology and Pathophysiology, School of Basic Medical Science, Tianjin Medical University, Tianjin 300070, China;2. Department of Rehabilitation and Sports Medicine, Tianjin Medical University, Tianjin 300070, China;3. Department of Pathology and Laboratory Medicine, School of Medicine, Temple University, Philadelphia, PA 19103;1. Department of Respiratory Medicine, Faculty of Medicine, University of Thessaly, Biopolis, Larissa, Greece;2. Department of Human and Molecular Genetics, Goodwin Research Laboratories, Massey Cancer Center, Virginia Commonwealth University, Richmond, VA, USA;3. Department of Integrative Physiology and Pathobiology, Tufts University School of Medicine, Boston, MA, USA;4. Department of Neurosurgery, Boston University, Boston Medical Center, Boston, MA, USA;5. Department of Physiology, Faculty of Medicine, University of Thessaly, Biopolis, Larissa 41500, Greece
Abstract:
Keywords:Sestrin  mTORC1  Nrf2  Keap1  p62  Autophagy  Free radicals
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