Manganese superoxide dismutase (SOD2/MnSOD)/catalase and SOD2/GPx1 ratios as biomarkers for tumor progression and metastasis in prostate,colon, and lung cancer |
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| Affiliation: | 1. Departamento de Morfología y Biología Celular, Facultad de Medicina y Ciencias de la Salud, University of Oviedo, Spain;2. Instituto Universitario Oncológico del Principado de Asturias (IUOPA), Oviedo, Spain;3. Department of Pathology, Hospital Universitario Central de Asturias, Oviedo, Spain;4. Department of Pathology, Hospital de San Agustin, Aviles, Spain;1. Government Post Graduate College, Karanprayag, Uttarakhand, 246444, India;2. School of Life Sciences, Jawaharlal Nehru University, New Delhi, 110067, India;3. Department of Biochemistry, Lucknow University, Lucknow, 226007, India;1. Department of Pathology and Laboratory Medicine, University of Pennsylvania, Philadelphia, PA;2. Division of Oncology, Department of Pediatrics, The Children''s Hospital of Philadelphia, University of Pennsylvania, Philadelphia, PA;3. Division of Bone Marrow Transplant and Immune Deficiency, University of Cincinnati College of Medicine, Cincinnati, OH;4. Division of Human Genetics, Cincinnati Children''s Hospital Medical Center, Department of Pediatrics, University of Cincinnati College of Medicine, Cincinnati, OH;5. Division of Cancer Predisposition, Department of Oncology, St. Jude Children''s Research Hospital, Memphis, TN;1. Grupo Multidisciplinar de Oncología Traslacional, Institut Universitari d’Investigació en Ciències de la Salut (IUNICS-IdISPa), Universitat de les Illes Balears, E07122 Palma de Mallorca, Illes Balears, Spain;2. Ciber Fisiopatología Obesidad y Nutrición (CB06/03), Instituto de Salud Carlos III, Spain |
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| Abstract: | The role of manganese-dependent superoxide dismutase (SOD2/MnSOD) during tumor progression has been studied for several decades with controversial results. While SOD2 downregulation was initially associated with tumor initiation and was proposed as a tumor suppressor gene, recent studies have reported that SOD2 might favor tumor progression and dissemination. To our knowledge this is the first time that changes in SOD2 expression in three different types of tumors, i.e., prostate, lung, and colon cancer, are studied by analyzing both SOD2 mRNA and protein levels in a total of 246 patients׳ samples. In prostate samples, SOD2 protein levels were also increased, especially in middle stage tumors. In the case of colon and lung tumors both mRNA and protein SOD2 levels were increased in malignant tissues compared to those in nontumor samples. More importantly, all metastases analyzed showed increased levels of SOD2 when compared to those of normal primary tissue and healthy adjacent tissue. Together, these results suggest that a common redox imbalance in these three types of tumor occurs at intermediate stages which then might favor migration and invasion, leading to a more aggressive cancer type. Consequently, the ratios SOD2/catalase and SOD2/Gpx1 could be considered as potential markers during progression from tumor growth to metastasis. |
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| Keywords: | SOD2 Redox state Prostate cancer Lung cancer Colon cancer Catalase Glutathione Peroxidase Hydrogen peroxidase |
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