首页 | 本学科首页   官方微博 | 高级检索  
     


Elevated plasma atrial natriuretic peptide in rats with myocardial infarcts
Authors:T Tikkanen  I Tikkanen  F Fyhrquist
Affiliation:1. Department of Cardiovascular Medicine, Kyoto University Graduate School of Medicine, 54 Kawahara-cho, Shogoin, Sakyo-ku, Kyoto 606-8507, Japan;2. Department of Medicine, Wakakusa Tatsuma Rehabilitation Hospital, Osaka, Japan;1. Department of Cardiovascular Medicine, Faculty of Medical Sciences, Kyushu University, Fukuoka, Japan;2. Research and Innovation-Nursing Institute, Kaufman Center for Heart Failure-Heart, Vascular and Thoracic Institute, Cleveland Clinic, Cleveland, OH, USA;3. University of Warwick, Warwick, UK, and Monash University, Clayton, Australia;4. Department of Cardiology and Berlin Institute of Health Center for Regenerative Therapies; German Centre for Cardiovascular Research partner site Berlin, Germany; Charité Universitätsmedizin Berlin, Germany;5. Institute of Heart Diseases, Wroclaw Medical University, Wroclaw, Poland;6. Heart Institute, Hospital Germans Trias i Pujol, CIBERCV, Badalona, Spain;7. Universitat Autonoma Barcelona, Spain;8. Baylor Scott and White Research Institute, Dallas, Texas, USA;9. University of Mississippi, Jackson, Mississippi, USA;10. Emergency Institute for Cardiovascular Diseases Prof. C.C. Iliescu Bucharest, University of Medicine Carol Davila, Bucharest, Romania;11. Inova Heart and Vascular Institute, Falls Church, Virginia, USA;12. Clinical Chief of Cardiology, University of Texas Southwestern Medical Center, Department of Internal Medicine/Division of Cardiology, Dallas, Texas, USA;13. Division of Cardiology, Duke University School of Medicine, Durham, North Carolina, USA;14. School of Medicine of National and Kapodistrian University of Athens, Athens University Hospital Attikon, Athens, Greece;15. Massachusetts General Hospital, Harvard Medical School and Baim Institute for Clinical Research, Boston, Massachusetts, USA;16. Second Department of Internal Medicine, Faculty of Medicine, University of Toyama, Toyama, Japan;17. Department of Cardiovascular Medicine, Shinshu University School of Medicine, Matsumoto, Japan;18. Department of Cardiovascular Biology and Medicine, Juntendo University Graduate School of Medicine, Tokyo, Japan;19. Duke Clinical Research Institute, Durham, Nortth Carolina, USA;20. Cardiology. ASST Spedali Civili and Department of Medical and Surgical Specialties, Radiological Sciences and Public Health, University of Brescia, Brescia, Italy;21. Division of Cardiology, Department of Medicine, University of Texas Southwestern, Dallas, Texas, USA;22. Centre for Clinical and Basic Research, Department of Medical Sciences, IRCCS San Raffaele Pisana, Rome, Italy;23. Department of Cardiovascular Medicine, Nara Medical University, Kashihara, Japan;24. Nara Prefecture Seiwa Medical Center, Sango, Japan;25. Department of Cardiovascular Medicine, Osaka University Graduate School of Medicine, Osaka, Japan;26. Department of Cardiovascular Medicine, Kawaguchi Cardiovascular and Respiratory Hospital, Kawaguchi, Japan;27. University of Belgrade Faculty of Medicine, Serbian Academy of Sciences and Arts, and Heart Failure Center, Belgrade University Medical Center, Belgrade, Serbia;28. Section of Cardiology, San Francisco Veterans Affairs Medical Center and School of Medicine, University of California San Francisco, San Francisco, California, USA;29. Department of Cardiovascular Medicine and Endocrinology and Metabolism, Faculty of Medicine, Tottori University, Yonago, Japan;30. Division of Cardiology, Department of Internal Medicine, The Jikei University School of Medicine, Tokyo, Japan
Abstract:We measured atrial natriuretic peptide (ANP) plasma levels in rats with experimental heart failure caused by left coronary artery ligation. ANP levels were clearly higher in infarcted rats (409 +/- 59 pg/ml; mean +/- S.E.M.) than in sham-operated controls (39 +/- 6 pg/ml). Moreover, plasma ANP levels increased progressively with the severity of cardiac dysfunction and size of infarct. Increased release of ANP in post-infarction heart failure appears to be a meaningful compensatory response to control rising preload. Our results are in keeping with evidence from human studies showing increased plasma concentration of ANP in patients with congestive heart failure. This model is a useful tool to further explore the role of ANP in heart failure.
Keywords:
本文献已被 ScienceDirect 等数据库收录!
设为首页 | 免责声明 | 关于勤云 | 加入收藏

Copyright©北京勤云科技发展有限公司  京ICP备09084417号