Characterization of the tandem CWCH2 sequence motif: a hallmark of inter-zinc finger interactions |
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| Authors: | Minoru Hatayama Jun Aruga |
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| Institution: | (1) Laboratory for Behavioral and Developmental Disorders, RIKEN Brain Science Institute, 351-0198 Wako-shi, Saitama, Japan;(2) Saitama University Brain Science Institute, 338-8570 Saitama-shi, Saitama, Japan |
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| Abstract: | Background The C2H2 zinc finger (ZF) domain is widely conserved among eukaryotic proteins. In Zic/Gli/Zap1 C2H2 ZF proteins, the two
N-terminal ZFs form a single structural unit by sharing a hydrophobic core. This structural unit defines a new motif comprised
of two tryptophan side chains at the center of the hydrophobic core. Because each tryptophan residue is located between the
two cysteine residues of the C2H2 motif, we have named this structure the tandem CWCH2 (tCWCH2) motif. |
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